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Spotkanie z Noblistą sir Peterem Ratcliffe’em // Understanding cellular oxygen sensing mechanisms: adventures of a physician in discovery science

lecture
📅 Date: 16 March 2023, Thursday

⌚ Start time: 13:30

📌 Place: Warsaw - Ochota dist., Żwirki i Wigury 101 (show on the map)
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[English version below]

Serdecznie zapraszamy do wzięcia udziału w wyjątkowym wydarzeniu - spotkaniu z sir Peterem Ratcliffe’em, laureatem Nagrody Nobla w dziedzinie fizjologii lub medycyny z 2019 roku, który został uhonorowany za swój wkład w odkrycie, jak komórki wyczuwają i adaptują się do dostępności tlenu.

Spotkanie z Noblistą sir Peterem Ratcliffe’em
Understanding cellular oxygen sensing mechanisms: adventures of a physician in discovery science
16 marca 2023, 13:30-15:00
Aula A+B, Centrum Nauk Biologiczno-Chemicznych UW, ul. Żwirki i Wigury 101, 02-089 Warszawa

Spotkanie będzie prowadzone w języku angielskim. Nie przewidujemy tłumaczenia symultanicznego. Wymagana jest rejestracja na wydarzenie >> link

Ponadto informujemy, że podczas realizacji projektu będą wykonywane zdjęcia oraz nagrania audio i wideo, które mogą zostać opublikowane w mediach społecznościowych oraz na stronach internetowych w domenie Uniwersytetu Warszawskiego oraz pozostałych organizatorów wydarzenia, Nobel Prize Outreach oraz AstraZeneca.


----- ENG -----

Take part in a unique event – a meeting with Sir Peter Ratcliffe, laureate of the Nobel Prize in Physiology or Medicine in 2019, who was honored for his discoveries of how cells sense and adapt to oxygen availability.

Abstract: The maintenance of oxygen homeostasis is a fundamental physiological challenge, inadequate oxygen (hypoxia) being a major component of most human diseases. The lecture will trace insights into human oxygen homeostasis from the founding work of William Harvey on the circulation of the blood to the molecular elucidation of a system of oxygen sensing that functions to measure oxygen levels in cells and control adaptive cellular and systemic responses to hypoxia. It will describe how work that commenced with studies of the regulation of the erythropoietin (EPO) gene by blood oxygen availability led to the unexpected discovery that the underlying oxygen sensitive process is present in all animal cells. The lecture will outline how the actual oxygen sensitive signal is generated by a set of ‘oxygen splitting’ enzymes that modify the key transcription factor (HIF) to signal its degradation (and hence inactivation) in the presence of oxygen. It will attempt to illustrate and rationalise the unexpected in biological discovery and discuss the interface of discovery science with the development of medical therapeutics.

The meeting will be held in English. We do not provide simultaneous translation. Please register for the event >> link

In addition, we would like to inform you that photos and audio and video recordings will be taken during the meeting, which may be published in social media and on websites in the domain of the University of Warsaw and other organizers of the event, Nobel Prize Outreach and AstraZeneca.